• Studies of early cell fate specification in the mouse

  2021-11-15

  

  Studies of early cell fate specification in the mouse embryo have identified a role for differential Motin localization in controlling Hippo signaling [88]. At the 32-cell stage, mouse blastomeres are subdivided into inner cells, which form the inner cell mass (ICM), and outer cells, which form the

• Finally we find that in the

  2021-11-15

  

  Finally, we find that in the absence of Aurora B, Sgo1 is delocalized from centromeres and found along chromosome arms, as reported after depletion of Bub1 (Kitajima et al., 2005, Riedel et al., 2006). The increased arm cohesion observed in the absence of Aurora B activity is dependent on the presen

• Following our initial observation of an

  2021-11-15

  

  Following our initial observation of an unexpected increase in the maximal rates of cGMP formation by NO-stimulated sGC in the presence of cytosolic PCA preparations [15], we attempted to purify, identify and characterize the responsible protein(s). The purification protocol described in the present

• flunixin meglumine br Materials and methods br Results

  2021-11-12

  

  Materials and methods Results Discussion Disclosures Author contributions Acknowledgements Introduction Diabetes mellitus is one of the fastest growing chronic diseases worldwide, with an estimated prevalence of 382 million patients, of which about 90% have type 2 diabetes melli

• The caseins are a family of

  2021-11-12

  

  The caseins are a family of milk phosphoproteins whose biological function is to provide supersaturating concentrations of calcium, phosphates, and essential N6-Methyl-dATP to the neonate (Vonderhaar and Ziska, 1989). α- and β-caseins, the most abundant of the milk caseins, are described as calcium

• When PKC was applied alone it attenuated

  2021-11-12

  

  When PKC19–31 was applied alone, it attenuated the activity run-down following excision. Furthermore, the activity induced by addition of PKC19–31 during PMA treatment in many cases was higher than in controls. Accordingly, in our experimental conditions, the mechanism which underlays channel inhibi

• Sickle erythrocytes are known to have

  2021-11-12

  

  Sickle erythrocytes are known to have an increased adhesion to endothelial (S)-AMPA (Hebbel et al., 1980, Hebbel et al., 1981a, Hebbel et al., 1981b, Wautier et al., 1985, Mohandas and Evans, 1987). Understanding the events associated with vaso-occlusion requires a detailed knowledge of the interac

• Initially we carried out gap FRAP experiments using the two

  2021-11-12

  

  Initially, we carried out gap-FRAP experiments using the two-photon configuration of the confocal microscope. A SR101-positive astrocyte was targeted and a 5 × 5 μm square area was exposed to a laser illumination (5 flashes of 5 s each during 25 s). This procedure resulted in a bleaching of this ast

• To evaluate the role of

  2021-11-12

  

  To evaluate the role of increased FPPS expression in paclitaxel-treated cells, we investigated the effects of FPPS on cannabinoid receptors progression. DNA content analysis showed that the number of cells accumulating in the G/M phase increased in a dose-dependent manner in paclitaxel-treated cell

• br Experimental procedures br Results br Discussion This

  2021-11-12

  

  Experimental procedures Results Discussion This study demonstrates that the genetic disruption or pharmacological inhibition of FAAH completely prevented all manifestations of pain symptoms in an NTG-induced migraine animal model. Thus, FAAH disruption or blockade abolished the activation o

• In this study we evaluated and

  2021-11-12

  

  In this study we evaluated and compared the kinetics and duration of the oral and systemic HPV-16 and HPV-18 specific antibody response to three doses of the qHPV vaccine in mid-adult aged HIV+ men from the AIDS Malignancy Cohort (AMC) 052 trial and mid-adult aged HIV− men from the Mid-Adult Male [M

• br Significance Cellular heterogeneity for phenotypic featur

  2021-11-12

  

  Significance Cellular heterogeneity for phenotypic features is a key mechanism underlying disease progression and therapeutic resistance, yet its regulation is poorly understood at the molecular level. Our findings demonstrate that endocrine resistance is associated with higher transcriptomic het

• br Introduction The coronary vasculature is required for sup

  2021-11-12

  

  Introduction The coronary vasculature is required for supplying oxygenated blood to the cardiac muscle. Proper coronary blood circulation is essential for embryonic and adult cardiac tissue homeostasis. Defects associated with the coronary function leads to myocardial ischemia, infarction, and he

• Over recent decades there were three breakthroughs

  2021-11-12

  

  Over recent decades, there were three breakthroughs of high intensity heavy-ion acceleration [6]. The first is the invention of radio frequency quadrupole (RFQ) type accelerator, which could accelerate more than dozens of milli-ampere ion beams and is a good solution to space-charge-effect of heavy-

• TC-E 5003 receptor br Acknowledgments The authors gratefully

  2021-11-12

  

  Acknowledgments The authors gratefully acknowledge the financial support of this study by STCU Project 6052 “Enzyme multibiosensor system for renal dysfunction diagnosis and hemodialysis control”. Furthermore, this study was supported by NASU in the frame of Scientific and Technical Program “Sens

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