• br Membrane Fusion Requires Rab GTPases Tethers and SNAREs

  2022-02-09

  

  Membrane Fusion Requires Rab-GTPases, Tethers, and SNAREs Regulation and Function of Rab5 Following endocytosis in metazoan cells, the Rab5-specific GEF Rabex5 binds to ubiquitinated cargo proteins, such as cell surface receptors or metabolite transporters, and subsequently activates Rab5 on e

• Although historically the two ROCK

  2022-02-09

  

  Although historically, the two ROCK isoforms have been viewed as redundant, recent observations show that the two isoforms of ROCK might have different functions (Newell-Litwa et al., 2015). Knockdown of ROCK1 was found to result in cell rounding and a decrease in cell size while cells with knockdow

• Increasing number of experimental data reveal that both ROS

  2022-02-09

  

  Increasing number of experimental data reveal that both ROS and RNS are multifunctional molecules playing a substantial role in plant physiology and particularly in seed biology (Bailly et al., 2008; Šírová et al., 2011; Yu et al., 2014). Dual function of RNS can be described by the model of “nitros

• Waldeck Weiermair et al demonstrated

  2022-02-09

  

  Waldeck-Weiermair et al. (2008) demonstrated that in endothelial cells, the activation of GPR55 by application of 10µM anandamide resulted in a marked increase of ERK1/2 phosphorylation that was evident 2min following drug activation and was sustained for up to 3h. Another example comes from our unp

• br Synthetic Antagonists for FFA To date

  2022-02-09

  

  Synthetic Antagonists for FFA4 To date, only compounds from a single chemical series have been reported as FFA4 ‘antagonists’ (Table 1). ‘Compound 39’ (4-methyl-N-9H-xanthen-9-yl-benzenesulfonamide), now available from commercial vendors as AH-7614, was initially reported as an antagonist at this

• The activation of the ERK pathway may participate in

  2022-02-09

  

  The activation of the ERK pathway may participate in the sensitization of primary afferents in pain transmission (Ji et al., 2009, Lai et al., 2011); the blockade of ERK activation in the DRG can decrease mechanical and heat hypersensitivity in inflammatory pain. IL-10 can inhibit phosphorylation of

• Ciclopirox A key limiting factor in the semi quantitative an

  2022-02-08

  

  A key limiting factor in the semi-quantitative analysis of changes in the nuclear-to-cytoplasmic distribution of glucokinase is the large intercellular heterogeneity of Ciclopirox of glucokinase in both isolated hepatocytes in vitro and also in liver in vivo[13], [23], [24], [26], [36]. This necess

• Olanzapine has been reported to attenuate insulin

  2022-02-08

  

  Olanzapine has been reported to attenuate insulin secretion, cause insulin resistance (Chintoh et al., 2008) and reduce whole body carbohydrate oxidation (Klingerman et al., 2014). However, a blunting of these effects in Gcgr−/− mice would not appear to explain the protection against olanzapine-indu

• Growth hormone secretagogue receptor GHSR is

  2022-02-08

  

  Growth hormone secretagogue receptor (GHSR) is a member of G-protein-coupled receptor family [3]. GHSR is predominantly expressed in human pituitary, rhypothalamus and hippocampus [4]. GHSR is also expressed in peripheral tissues including lungs, liver, kidney, and adrenal gland. In cardiovascular s

• Regulation of Gja involves a member of the

  2022-02-08

  

  Regulation of Gja4 involves a member of the wingless-type MMTV integration site family, WNT4. Mice deficient in Wnt4 had reduced (30%) expression of GJA1 compared to WT mice [40]. It is thought that WNT signaling regulates GJA1 expression and GJIC in granulosa GDC-0834 by modulating beta-catenin st

• Primarily because secretase was a therapeutic target in AD a

  2022-02-08

  

  Primarily because γ-secretase was a therapeutic target in AD, a plethora of γ-secretase inhibitors (GSIs) have been developed that effectively inhibit γ-secretase cleavage in humans [16]. Indeed, “druggability” of γ-secretase has not been an issue even when the identity of the target was unknown in

• No G C pattern managed to capture all

  2022-02-08

  

  No G4C pattern managed to capture all GQ forming sequences of the reference dataset. The sequences that were missed by even the most flexible models were AGATGGAGTGGAGAGG, AGGAGATGCAGGAG, AGAGGGTAGATGG and TTTTTAAAAGAAGGGGAGGAATAGGGGATATGA. In fact, the former three are not expected to form any unim

• br Introduction GPR also known

  2022-02-08

  

  Introduction GPR40 (also known as free fatty mm molarity receptor 1), a member of the G-protein coupled receptor (GPCR) family, is expressed in pancreatic beta cells, intestine and the central nervous system (Bekinschtein et al., 2008; Itoh et al., 2003). It is activated by medium- and long-chain

• The ETB receptor has been

  2022-02-08

  

  The ETB receptor has been shown to decrease sodium transport in the renal medullary collecting duct and medullary thick ascending limb of Henle10, 11, 12, 13, 18. However, both inhibitory and stimulatory effects of endothelin have been reported in the proximal tubule16, 47, 48, 49. In the rat, endot

• br Conflict of interest statement br Introduction

  2022-02-08

  

  Conflict of interest statement Introduction The Hedgehog (Hh) family of secreted protein signals patterns many tissues and structures during embryogenesis (Chiang et al., 1996, Dessaud et al., 2008, Ingham, 1993) and, post-embryonically, governs tissue homeostasis and regeneration by regulatin

15543 records 484/1037 page Previous Next First page 上5页 481482483484485 下5页 Last page